Cognitive Development and Grey Matter Enhancement via Auto-Generated Neural Impulse Modulation: A Speculative Framework for Alzheimer’s Risk Reduction

Shijo George*

Grey matter atrophy is a hallmark of Alzheimer’s disease (AD) and related dementias. This paper proposes a theoretical framework describing how “auto-generated neural impulses” (AGNI)—an umbrella term for endogenous stimulation patterns including homeostatic plasticity, neurotrophic regulation, and intrinsic oscillatory reinforcement—might influence grey matter density and cognitive resilience.

The paper develops non-actionable mathematical models, proposes theoretical molecular pathways, and explores speculative criteria for designing a hypothetical “cognitive-enhancing compound” that could, in theory, support neuroplasticity. These frameworks are intended to inspire academic discussion and are not meant as medical or laboratory protocols.

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Published on: Dec 9, 2025 Pages: 20-28

Full Text PDF Full Text HTML DOI: 10.17352/aadc.000032
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