Research Interest: Applications of Molecular
Imaging & Scanner in Diagnosis & Drug Development, Drug Development and
Discovery, Preclinical, Translational & Clinical Imaging. Pharmacological
Investigations and Intervention Studies, CNS disorders and disease, Oncology,
Cardiology and Neuro-cardiology, Inflammatory and Infectious disease, Metabolic
disorders, Transplantation and Regenerative Medicine, Biodistribution,
Pharmacokinetics and Metabolism of Drugs and Radiotracers,b
Research Interest: Elderly patients, Care of
patients affected with dementia in ambulatory, home and residential care
settings -Care of patients affected with neurodegenerative diseases-Neuropsy chopharmacology,Geriatric
pharmacology.
Research InterestElectrophysiological Assessment of Brain
Mechanisms of Visual, Auditory and Cognitive Processes, Neuropathology in
Patients with Neurological Disorders in Development and Aging
Dr. Chiara Villa is a post-doctoral fellow who started her research activity at Dept. of Neurological Sciences, University of Milan, Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico in 2006. In 2009 she obtained her PhD in Molecular Medicine. Her research activity was focused on genetic and expression analyses in order to clarify the effects of allelic variants in key genes on development and progression of two neurodegenerative diseases: Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). In 2014, she moved to the University of Milano-Bicocca and joined a research group working in the study of molecular bases of autism and sleep disorders, including restless legs syndrome (RLS) and nocturnal frontal lobe epilepsy (NFLE). Her work is now focused on applying her previous research experience in this field.
I
graduated with a Ph.D. in Human Anatomy and Histo-Embryology from Center for
Neuroscience at Zhejiang University in 2016. Following my doctoral studies, I
pursued postdoctoral research at the Center for Neurodegenerative Disease at
Emory University in the United States from 2017 to 2018 and continued
postdoctoral work at the College of Brain Science and Brain Medicine at
Zhejiang University from 2018 to 2021. In April 2021, I joined the faculty at
Hangzhou City University.
I
am a dedicated neuroscientist with a strong academic background and extensive
research experience in neurodegenerative and neurodevelopmental disorders.
Since my master's degree, I have been engaged in research on neurodegenerative
and neurodevelopmental disorders. As part of my master's studies, I
participated in two National Natural Science Foundation (NSFC) projects
concerning Alzheimer's disease (AD), systematically investigating the
pathologic mechanisms of olfactory dysfunction in the early stages of
Alzheimer's using mouse models. My Ph.D. research utilized autism mouse models
to reveal the impact of the autism-related gene Shank3 on the development of
cortical pyramidal neurons and discovered the role of the anterior cingulate
cortex in social deficits. These findings were published in the prestigious
journal Nature Neuroscience.
While
at Emory University, my research continued to focus on AD, with a particular
emphasis on the role of autophagy in the disease's pathological mechanisms.
During my postdoctoral training at Zhejiang University, I led a project funded
by the Youth Program of NSFC, investigating the role of calmodulin in neuronal
development and participated in in a key project of NSFC investigating the
coupling of neural activity to gene transcription in cognitive behavior, with
findings published in the journals Neuron and Cell Reports. Additionally, I
have been dedicated to studying the molecular control of biological age and
frailty in midlife females.
As
an associate researcher at Hangzhou City University, my research has primarily
focused on the molecular mechanisms of brain aging, with a keen interest in the
differences between males and females during the aging process and a commitment
to the development of anti-aging drugs. My work has been supported by a
Zhejiang Provincial Natural Science Foundation project.
My
research has been recognized with the publication of 33 SCI papers as the first
author or co-author in journals such as Neuron, Nature Neuroscience, and Cell
Reports. These publications have received over 715 citations, reflecting the
impact of my work on the scientific community. Additionally, I hold two
authorized invention patents, showcasing my ability to translate scientific
discoveries into practical applications.
My
current position as an Associate Research Fellow at Hangzhou City University
allows me to continue my research on the molecular mechanisms of aging and
neurodegenerative diseases. I am passionate about contributing significantly to
the field and improving human health through a better understanding of the
brain. I am committed to mentorship and education, guiding the next generation
of neuroscientists at Hangzhou City University.
In
summary, my dedication to neuroscience, my commitment to mentorship, and my contributions
to the scientific community have shaped my career as a researcher. I am
inspired by the potential of my work to improve the lives of those affected by
neurodegenerative conditions and to advance our collective understanding of the
brain.
Research Interests: My
research interests are interdisciplinary, combining cellular and molecular
biology, neurophysiology, and translational medicine approaches to address
significant questions in neuroscience. I am particularly focused on unravelling
the mysteries of Alzheimer's disease and the molecular control of biological
age and frailty, especially in midlife females. Meanwhile I am dedicated to
explore the effects of chronic stress on brain aging which may provide valuable
insights into the interplay between psychological stressors and physiological
changes within the brain.
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