Recent Developments on Alzheimer’s Intervention: A Mini Review

Aina Oluwafemi S* and Ojini Kelechi I

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta plaque deposition, tau protein tangles, neuronal loss, and cerebral atrophy, leading to cognitive decline and memory impairment. Traditionally, treatments have primarily addressed symptoms without targeting the disease’s underlying pathology. However, recent advances have spurred the development of disease-modifying therapies aimed at halting or reversing AD progression. This review highlights key therapeutic strategies, including targeting amyloid-beta and tau protein pathology, natural compounds like curcumin and resveratrol, and anti-inflammatory or antioxidant approaches. Emerging evidence suggests that bacterial infections, such as Porphyromonas gingivalis associated with periodontal disease, may contribute to AD pathogenesis through mechanisms involving neuroinflammation and amyloid production. Novel therapeutic approaches leveraging computational drug discovery and combinatorial treatments offer promising avenues for combating this multifaceted disease. By integrating insights from both traditional and emerging research, this review underscores the importance of a multi-modal strategy in addressing Alzheimer’s disease.

Keywords:

Published on: Jul 3, 2025 Pages: 11-16

Full Text PDF Full Text HTML DOI: 10.17352/aadc.000030
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat